The end of dental implants?

Is this the end of dental implants? The development of a revolutionary drug by Japanese researchers promises the growth of teeth in patients who have lost their permanent teeth. So far the formula has been a success in tests carried out with laboratory ferrets and in July it will be tested on humans.
This drug ‘that makes teeth grow’ bases its action on an antibody that blocks the gene that codes for the production of the USAG-1 protein. This is produced naturally in the body and suppresses the growth of teeth after a certain age.

Dr. Tarsys Loayza Roys talks about this new advance
Doctor Tarsys Loayza Roys, general director of the spa-type clinic Sonrisa Perfecta Dental, analyzes the implications of this advance in dentistry. Based on her knowledge and research in areas such as microbiology, molecular and clinical genetics, prosthodontics and periodontics; she evaluates the possible consequences.
The first clarification she makes is that it is not yet a defined formula or an invention ready to be commercialized on the market. There is still a way to go. She asserts that nothing can be taken for granted, as one of the longest and most demanding stages of any pharmaceutical research begins. These are tests on human beings.
The clinical trials will take place between September of this year and August 2025. They will take place at Kyoto University Hospital and they have already announced that they will expand the tests to include child patients (2 to 7 years old) who suffer from genetic edentulism. All this will only lengthen this testing phase.
This professional, recognized as one of the best Colombian dentists, points out that, in the best of cases, the drug will be available in 2030. She adds that this means that at least until then, the reign of dental implants and prostheses at the level world will continue as before. She warns that even if this drug enters the market, it will take years for it to truly be available worldwide.

More expensive than dental implants?
The general director of the spa-type clinic Sonrisa Perfecta Dental warns of another drawback and it has to do with costs. Currently, each implant with abutment and its respective crown can have a value of less than 2,000 US dollars. Many patients who come to the consultation only require 1, 2 or 3 dental implants to replace natural teeth that they have lost for various reasons.
For these people, the drug being developed by the Toregem BioPharma laboratory may not be an attractive alternative. It is due to the high cost of the medication. The same scientists in charge of making the announcement project that the final product could cost about $9,800 per vial. They have not specified how many bottles a person will require to achieve a total replacement of lost teeth.
As if that cost were not enough, the same researchers have warned that the price of the drug could increase after a single dose. For Dr. Tarsys Loayza Roys, it is an indirect statement that a patient may need more than one vial.

A new advance that must be observed with caution
For this Colombian dentist, the announcement by the Japanese laboratory Toregem BioPharma is a momentous event for dentistry. It is regardless of whether it means the beginning of the end of dental implants. Dr. Tarsys Loayza Roys thinks that dentures and dental implants will continue to dominate the oral rehabilitation market.
The drug ‘that makes teeth grow’ is an advance that must be observed with caution and reserve. At least, it must be done while the conclusions of the clinical trials in humans are known. She predicted that if it finally reaches the market, it would be an important discovery that would contribute enormously to health. Its biological behavior would be a contribution to the genetic field at a global level.
The doctor stands out especially in people with chromosomal alterations or who, due to immunological incidence, present alterations in the tooth germ. “Patients with partial or total absences of embryonic origin among other physiological conditions would benefit enormously,” she points out. For her, it would be an unprecedented contribution in the clinical and social field.
She recalled that she has always been at the forefront of all advances in dentistry and aesthetics and this time will be no exception. “We will be waiting for a revolutionary clinical and molecular study that would significantly impact the entire society on a scientific and oral health level,” she added.

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